Christian Atsu will be missing from the squad with a virus and will join Aiden McGeady (knee), Bryan Oviedo (hamstring), Tony Hibbert (muscle), John Stones (suspended) and Aaron Lennon (ineligible).
Sylvain Distin is fit and available for selection and could be joined by Leon Osman and Steven Pienaar who are back in training after a game with the rezzies.
Romelu Lukaku, Steven Naismith, Mo Besic and Steven Pienaar all have 2 bookings. If they get a third tonight, they will miss the first leg game in the next round.
With 3 wingers Atsu, Lennon and McGeady all missing, the stage is set for Kevin Mirallas to start.
Roberto said: "We're still hoping that we're going to get a couple of players back. Its been disappointing to lose Bryan Oviedo and Aiden McGeady of late.
"We're going to assess Leon Osman and Steven Pienaar but they are looking ready to make the squad, and that's important.
"Christian Atsu is going to miss out on the squad through illness, he's got a virus, Tony Hibbert is still recovering and hasn't been able to join the group but Sylvain Distin is fully fit and available.
"We're going to try to be as strong as we can be in the game tomorrow and on Sunday and then again on Wednesday at Stoke City.
"It's going to be a really demanding week and it's important we've got everybody in the squad ready."
Everton squad: Howard, Coleman, Jagielka, Alcaraz, Baines, McCarthy, Barry, Besic, Naismith, Barkley, Lukaku, Osman, Pienaar, Distin, Browning, Garbutt, Robles, Gibson, Kone, Mirallas, Kenny, Ledson.
Jogger's Starting XI: Howard, Coleman, Jagielka, Alcaraz, Baines, McCarthy, Barry, Mirallas, Naismith, Barkley, Lukaku.